Henry Harrison Lewis, Jr. was a native of Buffalo was born circa June 1862. During the 1901 Pan American Exposition, Lewis was appointed to the Committee of Comfort. The Committee was created by the Board of Managers of the Exposition and included other notable African Americans such as Mary Burnett Talbert, Rev. J. Edward Nash and James Ross. The purpose of the Committee was to assist African American visitors with accommodations during their stay in the city.
Harrison worked as a bank employee, variously filling jobs such as messenger and "special officer".
Harris was married to Susie Binga Lewis and had one son, Henry, III. who became a physician. Mrs. Lewis was a seamstress.